Triyandi, Ramadhan and Iqbal, Muhammad and Sayoeti, Muhammad Fitra Wardhana and Ramdini, Dwi Aulia and Puteri, Vadiyani Fricillya and Palogan, Afna Nur Afni and Fredison, Fredison and Amrillah, Nur and Kanedi, Mohammad BURNS HEALING RATES IN RATS MEDICATED WITH LEAF EXTRACT OF TEKELAN (CHROMOLAENA ODORATA L.) OINTMENT. WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES. ISSN 2278 – 4357

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Abstract

Tekelan (Chromolaena odorataL.) is a type of plant that is known to contain antioxidants, anti-inflammatory, and antimicrobial properties that allow this plant to be used as a wound healing medicine, including burns. This study aims to determine the healing effect of ethanol fraction of tekelan leaf extract on wistar rats (Rattus norvegicus). By using completely randomized design five different ointments were prepared and given to five groups of experimentalanimalsconsisted of three rats each.To the each group,the treatments given are as follows: silver sulfadiazine cream (+ control), vaseline flavum (–control), tekelan extract of 5%, 10% and 15% respectively (as the test groups). Burn wound is inflicted by placing a metal rod (12mmdiameter)heated to 100oC in boiling water onthe back skin of rats that had beenpreviously shaved. Treatment wasgiven once daily for 21 days. Observation of wound healing, based on percent closure wound area, was carried out on day 0 (immediately after the injury), day 7, 14 and 21.The results showed that all treatments could completely heal burns in test animals within 21 days. The only difference was seen in the weekly progress rate of wound closure, where only the tekelanextract with the highest concentration (15%) nearly matched the standard drug.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Depositing User:	Ramadhan Triyandi
Date Deposited:	08 Jun 2021 08:49
Last Modified:	08 Jun 2021 08:49
URI:	http://repository.lppm.unila.ac.id/id/eprint/32321

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