Kamiya, Kentaro and Arai, Masayoshi and Setiawan, Andi and Kobayashi, Motomasa (2017) Anti-dormant Mycobacterial Activity of Viomellein and Xanthomegnin, Naphthoquinone Dimers Produced by Marine�derived Aspergillus sp. Natural Product Communications, 12 (4). pp. 579-581. ISSN 15559475, 1934578X

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Official URL: https://journals.sagepub.com/doi/abs/10.1177/19345...


In the course of a search for anti-dormant mycobacterial substances from marine-derived microorganisms, viomellein (1) and xanthomegnin (2) were re�discovered from the active fraction of the culture of a marine-derived Aspergillus sp. together with rubrosulphin (3) and asteltoxin (4) on the guidance of bioassay-guided separation. In particular, compound 1 showed higher activity against the dormant than against actively growing Mycobacterium bovis BCG and weak activity against M. smegmatis. Furthermore, evidence that compound 1 did not directly bind to plasmid DNA suggests its anti-mycobacterial activity differs from its direct chelating effect on the mycobacterial genome. Keywords: Viomellein, Marine-derived Aspergillus sp., Antibiotics, Tuberculosis, Dormant.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof Andi Setiawan
Date Deposited: 06 Jun 2021 14:35
Last Modified: 06 Jun 2021 14:35
URI: http://repository.lppm.unila.ac.id/id/eprint/32129

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