Arai, Masayoshi and han, chisu and Yamano, Yoshi and Setiawan, Andi and Kobayashi, Motomasa (2014) Aaptamines, marine spongean alkaloids, as anti-dormant mycobacterial substances. J Nat Med, 68 (2). pp. 372-376. ISSN 13403443, 18610293

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Official URL: https://doi: 10.1007/s11418-013-0811-y.


A new aaptamine class alkaloid, designated 2-methoxy-3-oxoaaptamine (1), together with seven known aaptamines (2–8) were isolated from a marine sponge of Aaptos sp. as anti-mycobacterial substances against active and dormant bacilli. The chemical structure of 1 was determined on the basis of spectroscopic analysis. Com�pound 1 was anti-mycobacterial against Mycobacterium smegmatis in both active growing and dormancy-inducing hypoxic conditions with a minimum inhibitory concentra�tion (MIC) of 6.25 lg/ml, and compounds 2, 5, 6, and 7 showed anti-mycobacterial activities under hypoxic con�dition selectively, with MIC values of 1.5–6.25 lg/ml

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof Andi Setiawan
Date Deposited: 06 Jun 2021 14:34
Last Modified: 06 Jun 2021 14:34

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