Widiastuti, E.L. (2016) Ameliorative effects of Costus speciosus on biochemical and histopathological changes in alloxan-induced diabetic mice. Science Letters, 4 (2). pp. 140-146. ISSN 2311-3219

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The present study evaluated the ameliorative effects of Costus speciosus (CS) on biochemical and histopathological changes in alloxanized mice. Diabetes was induced in mice by administration of alloxan monohydrate (0.65mg/100g BW). Root extract of CS (10, 20 and 50 mg/100g BW) and metformin (19.5 mg/100g BW) as the standard drug were administered orally using a gavage to alloxanized mice daily for 14 days.Our study showed that oral administration of CS significantly decreased the blood glucose and total serum cholesterol levels. Moreover, CS restored the altered plasma enzyme (AST, ALT, LDH, ALP and ACP) levels. The reversal in liver and pancreatic histopathology further supports the protective effect of the CS extract towards diabetic damage. Extract of CS is effective in controlling blood glucose in diabetes and protecting liver and pancreatic tissues from diabetic damage. However, further studies are indeed required to prove the safety and efficacy of CS extracts as a potential anti-diabetic agent in clinical practices. Keywords Alloxan, biochemical changes, Costus speciosus, Diabetes mellitus, histopathology, mice.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Date Deposited: 02 Jun 2017 12:23
Last Modified: 02 Jun 2017 12:23
URI: http://repository.lppm.unila.ac.id/id/eprint/2899

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