Suhartati, Tati and Yandri, Yandri and Suwandi, Jhons Fatriyadi and Yuwono, Suripto D. and Qudus, Hardoko Insan and Hadi, Sutopo (2020) In Vivo Antimalarial Test of Artocarpin and in vitro Antimalarial Test of Artonin M Isolated from Artocarpus. Revista de Chimie, 71 (5). pp. 400-408. ISSN 2668-8212
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Abstract
Abstract: The derivative of flavonoid compounds, artocarpin (1) and artonin M (2), were isolated from the root wood of Artocarpus altilis and from the root bark of A. kemando, respectively. Both plants originated from Lampung, Indonesia. The structure of the two compounds has been carefully determined by physical method and spectroscopy techniques of UV, IR, and NMR. The in vivo antimalarial test of artocarpin showed very good Plasmodium activity in female mice, with ED 50 value of 34.88 mg/kg body weight (kgBW), whereas the in vitro antimalarial test of artonin M showed very strong activity with IC 50 of 0.3 μg/mL (5.967 x 10 -7 M).
| Item Type: | Article |
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| Subjects: | Q Science > QD Chemistry |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia |
| Depositing User: | Prof. YANDRI AS |
| Date Deposited: | 09 Mar 2021 07:10 |
| Last Modified: | 09 Mar 2021 07:10 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/28291 |
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