Hadi, Sutopo and Irawan, Bambang and Suhartati, Tati and Yandri, Yandri (2021) Synthesis, characterization and the antifungal activity test of some organotin(IV) benzoates. Journal of Physics: Conference Series, 1751. 012099. ISSN Print : 1742-6588 Online : 1742-6596


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Official URL: https://iopscience.iop.org/issue/1742-6596/1751/1


In continuing search on the biological activity of the organotin compounds we are working with, We here reported the synthesis and the antifungal activity test of three organotin(IV) complexes of dibutyltin(IV) dibenzoate (3), diphenyltin(IV) dibenzoate (6) and triphenyltin(IV) benzoate (9). These three compounds were prepared by the reaction of dibutyltin(IV) dichloride (1), diphenyltin(IV) dichloride (4), and triphenyltin(IV) chloride (7) via dibutyltin(IV) oxide (2), diphenyltin(IV) oxide (5), and triphenyltin(IV) hydroxide (8) with benzoic acid. The product obtained in each step was characterized by UV, IR and NMR spectroscopies and also microelemental analysis. The antifungal activity test was carried out against Fusarium oxysporum strain. The results showed that the inhibition zone shown by these organotin(IV) benzoate were found by far much more active compared to the free benzoic acid, the starting materials 1, 4, 7, and the intermediate products, 2, 5 and 8. The inhibition zone of each of the compounds tested was compared with the control where the fungus alone was grown in the media. The results showed that triphenyltin(IV) benzoate (9) was the most active compound against the fungus and the minimum inhibitory concentration obtained was about 0.7 mM.

Item Type: Article
Uncontrolled Keywords: antifungal, organotin(IV) benzoate, minimum inhibitory concentration, synthesis
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof. Sutopo Hadi
Date Deposited: 01 Feb 2021 04:51
Last Modified: 01 Feb 2021 04:51
URI: http://repository.lppm.unila.ac.id/id/eprint/27521

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