Kanedi, Mohammad and Sutyarso, Sutyarso and Nurjanah, Siti and Wahidah, Lilik Koernia (2016) Testicular Dysfunction in Male Rats Reversed by Ethanolic Extract of Pitaya Fruit. Journal of Diseases and Medicinal Plants, 2 (4). pp. 51-55. ISSN 2469-8210

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Abstract

Abstract: Sexual disorders have a great impact on men's life, so that is why efforts in searching materials and techniques for the effective treatment of safe and cheap still continued. However, many of the natural material that is claimed efficacious drugs for the high content of bioactive, particularly for sexual disorders, has not been scientifically tested. This study was designed and conducted to ascertain whether the dragon fruit (Hylocereus sp) which is claimed to be efficacious as an antioxidant as well as anti-aging, can be used as a remedy for sexual function disorders and fertility in male rats. Male Sprague-Dawley rats (Rattus novergicus) aged 10 – 12 weeks, grouped in to four consisted of six rats each, treated once daily for 25 days. Group 1 (control) was given 1 ml CMC 1%; group 2 received extract of pitaya fruit at a dose of 500mg/kg; group 3 treated with cyproterone acetate (CPA) at a dose of 25mg/kg; whereas group 4 adminstered with 25mg/kg CPA and 500mg/kg of pitaya fruit extract. CPA treatment effectively reduces serum testosterone while pitaya fruit extract effectively enhances the androgen concentration; increases spermatozoa counts, sperm viability, sperm motility, and spermatid counts. However, pitaya fruit fail to restore the decrease of primary spermatocyte due to CPA induction. So, the conclusion white pitaya fruit extract effectively increase the synthesis of testosterone and play a role spermiogenesis, thus the pitaya fruit herbs can be used as an enhancer of sexual activity and fertility in male.

Item Type:	Article
Subjects:	Q Science > QP Physiology
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Depositing User:	SUTYARSO
Date Deposited:	02 Jun 2017 06:36
Last Modified:	02 Jun 2017 06:36
URI:	http://repository.lppm.unila.ac.id/id/eprint/2720

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