Evi, Kurniawaty and Frisca, Febe Lumban Gaol and Intanri Kurniati, Intanri Kurniati and Silvia, Andriani and Soraya, Rahmanisa and Silvia, Andriani Effect Of Giving Ethanol Jengkol Seeds (Pithecellabium lobaium Bcnth.) On The lmprovcment OfUreum And Creatinine Levels Of White Rat. Systematic Reviews in Pharmacy, 11 (12). pp. 407-408. ISSN 0975-8453

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Abstract

Abstract Purpose: Diabetes Mellitus is a degenerative disease which is a chronic disease caused by the failure of the pancreas to produce insulin. Diabetes Mellitus is characterized by polyuria, polydipsia, and polyphagia, accompanied by an increase in blood glucose. Diabetes mellitus triggers many complications, one of which is kidney problems. Jengkol is a type of plant that can lower blood sugar levels, but it can also cause acute kidney failure due to the jengkolic acid content in it. To diagnose acute renal failure, it is necessary to examine kidney function by measuring levels of urea and creatinine. Research Methodology: This research is an experimental study with a Post Test Only Control Group Design. The sample in this study were male white rats (Rattus novergicus) Sparague Dawley strain with a body weight of 200-250 grams, aged 3-4 months, totaling 25 animals, which were divided into 5 groups. Results: Based on the results of the oneway ANOVA test, it was found that the p value> 0.05 jengkol seed extract had no effect on the increase in urea and creatinine levels of sparague dawley rats induced by alloxan. However, when viewed from the mean creatine level at a dose of 1200 mg / kgbb, the ethanol extract of jengkol seeds can cause an increase in creatinine levels with a group mean value of 0.08mg / dl. Limitations: This research is expected to be the basis for further researchers regarding jengkol extract as a therapy for kidney failure Contribution: Bandar lampung, Biologi Molekuler Keywords: Alloxan, Glucose, creatinine, and polyura.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Depositing User:	EVI KURNIA
Date Deposited:	18 Jan 2021 01:05
Last Modified:	18 Jan 2021 01:05
URI:	http://repository.lppm.unila.ac.id/id/eprint/27096

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