nurjanah, siti and samsuar, s and nopiyansah, n and Lande, Martha L. and Kanedi, Mohammad (2017) Duretic Activity of Plant Extract of Garden Spurge (Euphorbia Hirta L.) on Male Wistar Rats. European Journal of Biomedical and Pharmaceutical Sciences, 4 (01). pp. 516-519. ISSN 2349-8870

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Abstract

Because of its wide uses in many folk medicine system, the garden spurge (eurphorbia hirta L.) is worth mentioning as a versatile herb plant. However, in relation to renal function, research result on the efficacy of this plants have not give a consistent result. this study, for that reason, aimed to reveal and verivy the effect of ethanol extract of E. hirta against output of rat urine by using furosemide as reference. three different doses of whole plant extract of E. hirta (38.67, 77.35, 154.7 mg/kg), furosemide (3,6 mg/kg) and distilled water (as negative control) were orally administered to the fasted healthy male rats. the urinary parameters assessed were the urine volume hourly for 6 hours, urine pH and urine color density. The result showed extract of E. hirta at the dose of 77.35 mg/kg and 154.7 mg/kg significantly increase urine volume in comparison to the negative control but showed no difference with furosemide (alpha= 0.005). However, all treatments showed no statistical difference in the urine pH and urine color scores. Thus, it can be conclude that the whole plant ethanolic extract of patikan kebo potentially for diuretic herb without make significant changes on pH and color of the urine output. Keywords: Garden spurge, Patikan kebo, Eurphorbia hirta, diuretic activity, urine pH, urine color

Item Type:	Article
Subjects:	Q Science > Q Science (General) Q Science > QK Botany Q Science > QL Zoology S Agriculture > S Agriculture (General) S Agriculture > SB Plant culture S Agriculture > SF Animal culture
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Depositing User:	Dra. Mieta Martha Lulus Lande
Date Deposited:	02 Jun 2017 05:47
Last Modified:	02 Jun 2017 05:47
URI:	http://repository.lppm.unila.ac.id/id/eprint/2649

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