Widiastuti, E.L. and Ardiansyah, B.K. and Nurcahyani, Nuning and Silvinia, Ade (2020) Antidiabetic Potency of Jeruju (Acanthus ilicifolius L.) Ethanol Extract and Taurine on Histopathological Response of Mice Kidney (Mus musculus L.) Induced by Alloxan. IOP Conf. Series: Earth and Environmental Science. ISSN 1755-1315
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Abstract
Diabetes arises due to interference with the work of the pancreas in secreting the hormone insulin. The disease can cause a decrease in body immunity and complications of various vital organs such as the kidneys. Jeruju (Acanthus ilicifolius L.) leaf and taurine is reported to have antioxidant activity that is potential as antidiabetic agents. The purpose of this study was to determine the effect of jeruju and taurine on blood glucose levels and the ability to regenerate kidney organs damaged by alloxan induction. This study used a Completely Randomized Design with 5 treatment groups and 5 replications each. K1 group as a negative control (no treatment given), K2 group as a positive control (only induced by alloxan), group P1 induced alloxan and given 100% ethanol extract of jeruju leaf 22.4 mg/bw/day, group P2 induced alloxan and given alloxan 50% ethanol extract of jeruju leaf dose 22.4 mg/bw/day, group P3 was induced by alloxan and given a taurine dose of 15.6 mg/bw/day for 14 days. Data were analyzed by ANOVA followed by LSD at 5% of significant level. The results showed that the administration of jeruju extract and taurine affected the bodyweight of mice, and was significantly able to reduce blood glucose levels by 69.39% (P1), 67.06% (P2), 73.77% (P3), able to repair kidney damage after alloxan induction.
| Item Type: | Article |
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| Subjects: | Q Science > QL Zoology |
| Divisions: | Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi |
| Depositing User: | DR ENDANG LINIRIN WIDIASTUTI |
| Date Deposited: | 19 Nov 2020 11:34 |
| Last Modified: | 09 Sep 2022 09:19 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/26252 |
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