Ambarwati, Yuli and Martoprawiro, Muhamad A. and Mulyani, Irma and Onggo, Djulia Mengikuti Seminar Internasional dengan judul "Docking Interaction of Chromium(III) Picolinate and Chromate Ion Compounds with Protein Tyrosine Phosphatase as Insulin Receptors". In: ICASMI 2020, 3 September 2020, Bandar Lampung. (Submitted)

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The Chromium(III) compounds have been shown to reduce glucose levels in type 2 diabetics, however, the role of chromium(III) in glucose metabolism cannot be clearly explained. Based on in vitrostudies, there are two opinions regarding the mechanism of the role of chromium(III), the first opinion states that the chromium(III) that enters the body directly interacts with protein tyrosine phosphatase. Second opinion, chromium(III) which enters the body undergoes oxidation to become chromium(VI), and chromium(VI) interacts with protein tyrosine phosphatase. To determine the mechanism that occurs, modeling using chromium(III) picolinate as a chromium(III) complex and chromate ion as chromium(VI) interacts with protein tyrosine phosphatase. The structure optimization of chromium(III)picolinate compounds and chromate ions was carried out using the Hartree-Fock computation method based on the 6-31G (d) set. The interaction study was studied using the Autodock Vina and ONIOM docing methods. The interaction results of chromium(III) picolinate docking interact with Leu(13), Ile(16), Ser(47), Trp(49), Asn(50),and Tyr(131) with interaction energy of -7.00 kcal.mol-1. Chromate ion interacts with amino acids Leu(13), Gly(14), Ile(16), Cys(17) and Arg(18) with an interaction energy of -4.10 kcal.mol-1. The result of interaction energy of chromium(III) picolinate is lower than that of chromate ion, which indicates that the interaction of chromium(III) picolinate with protein tyrosine phosphatase is better than that of chromate ion

Item Type: Conference or Workshop Item (Speech)
Subjects: Q Science > QD Chemistry
Depositing User: Dr YULI AMBARWATI
Date Deposited: 18 Nov 2020 01:37
Last Modified: 18 Nov 2020 01:37

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