Ambarwati, Yuli and Bahri, Syaiful and Hadi, Sutopo and Laila, Aspita Synthesis Of Cr(III)-Aspartate And Cu(II)-Aspartate Complexes As Antidiabetic Compounds. Ravista de chemie. (Submitted)

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Abstract

Abstract: The synthesis of Cr(III)-Aspartate and Cu(II)-Aspartate complexes has been successfully carried out, by reacting CrCl3.6H2O and CuCl2.2H2O metals with aspartate acid. This study aims to synthesize Cr(Asp)2Cl2 and Cu(Asp)Cl2 and to test the antidiabetic. The results of the synthesis of Cr(Asp)2Cl2 in the form of light purple solid as much as 0.3001 grams with a yield of 95.14% and Cu(Asp)Cl2produced blue solids of 0.3095 grams with a yield of 95.02%. The antidiabetic test used 27 male mice (Mus musculus) with 9 treatments for 21 days and the data obtained were analyzed statistically using ANOVA (Analysis of Variance) and the antidiabetic activity was expressed in %GL (glucose lowering). The antidiabetic test showed a decrease in blood glucose levels in mice after alloxan induction, with %GL values of 74.1874% for Cr(Asp)2Cl2 compounds and 76.1337% for Cu(Asp)Cl2 compounds. This study proves that the Cr(Asp)2Cl2 and Cu(Asp)Cl2 complex compounds can be used as antidiabetic in mice.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Dr YULI AMBARWATI
Date Deposited:	17 Nov 2020 03:05
Last Modified:	17 Nov 2020 03:05
URI:	http://repository.lppm.unila.ac.id/id/eprint/25703

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