Kanedi, Mohammad (2020) Analgesic activity of the combined extract of sukun (Artocarpus altilis) and melinjo (Gnetum gnemon L.) Leaves in mice. GSC Biological and Pharmaceutical Sciences,, 13 (1). pp. 244-250. ISSN 2581-3250,

64.Analgesic activity of the combined extract of sukun_GSCBPS-2020-0344.pdf

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Analgesic is any drug used to achieve analgesia—relieve from pain, without blocking the conduction of nerve impulses. Sukun (Artocarpusaltilis) and melinjo (Gnetumgnemon L.) are plants that can be expected to have analgesic properties because they contain bioactive that can inhibit biosynthesis of prostaglandins, a hormone-like pain reducing agent. To determine analgesic effect of two plants in question, the combination extract of melinjo and sukun leaves were treated to mice by applying writhing test. Male mice (n=28) were grouped into seven consisted of two control groups (negative dan positive) and five test groups. The negative control group (KN) received CMC 0.5%, the positive control mice received 1.3 mg/kg BW mefenamic acid. Test groups were given leaf extracts of sukun and melinjo with the dose ratios (sukun : melinjo) as follows (200: 0), (150 : 50), (100 : 100 ), (50 : 150), and (0 : 200) mg/kg BW respectively. After 15 minutes all mice were pain-induced with 1% acetic acid intraperitoneally. Stretching activity of the animals was observed every 5 minutes for 1 hour. The result showed that the extracts with a dose ratio of (150 + 50) mg/kg BW has a comparable anlgesic effects to the mefenamic acid is the most effective combination among other comination doses.

Item Type: Article
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Depositing User: Drs.M.Si. Mohammad Kanedi
Date Deposited: 16 Nov 2020 01:42
Last Modified: 16 Nov 2020 01:42
URI: http://repository.lppm.unila.ac.id/id/eprint/25332

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