A, Suharyadi and Sukohar, Asep and Muhartono, Muhartono (2014) The Effects of Soursop Leaf Ethanol Extract on Renal Histopathological Analysis of DMBA Induced. Medical Journal of Lampung University, 3 (4). pp. 27-34. ISSN 2337-3776

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The soursop (Annona muricata Linn) are widely used in traditional medicine. The findings of active compounds of Soursop leaf are antioxidants and anti-inflammatory. This study suggest that soursop leaf extract has a protective effect against renal histopathologic damage and determine the relationship of increasing the doses of soursop leaf extract with renal damage in rats (Rattus norvegicus). Design was using completely randomized experimental with 5 groups, G1 (aquades), G2 (DMBA 75 mg/kg body weight), G3, G4 and G5 given the same dose of DMBA (75mg/Kg body weight) and soursop leaf extract with different doses (100, 200 and 400 mg /kg body weight). The number of samples 25 rats and each group contained 5 rats. The test used was Kruskalwallis (p<0,05) test, Post-hoc Mann Whitney (p<0,05) test. The results showed a mean score of renal damage in G1: 0,16±0,83; G2: 2,44±1,09; G3: 2,24±0,83; G4: 1,96±0,83; G5: 1,48±0,54. Conclusion, the dose of 400 mg/kg body weight was the most effective dose in the inhibition of renal damage.

Item Type: Article
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisions: Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter
Depositing User: Dr. ASEP SUKOHAR
Date Deposited: 31 Aug 2016 03:52
Last Modified: 04 Nov 2016 02:58
URI: http://repository.lppm.unila.ac.id/id/eprint/251

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