Hadi, Sutopo and Noviany, Noviany and Suhartati, Tati (2020) The Potential Application of Organotin(IV) Carboxylate Compounds in Medicinal Chemistry. In: Virtual Conference on Chemistry and its Applications, 1-31 August 2020, Mauritius.

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Abstract

The organotin(IV) carboxylate and its derivatives are widely known since the derivative of these compounds are very active and strong even at very low concentration [1]. Thus, these compounds continue to attract more attention to be used in many biological activities such as anti-cancer [2,3], antimalarial [4], anti-bacterial [5] and anti-fungi [6]. We have previously synthesized and performed some activity studies of organotin(IV) benzoates [3-6]. In this work, we reported the anti-bacterial and antimalarial activity studies of some organotin(IV) derivatives. The targeted compounds were prepared from their organotin(IV) chlorides via the intermediate products of dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, respectively, followed by reacting the intermediate products with some carboxylic acids. The anti-malaria activity was performed against Plasmodium falcifarum. While the anti-bacterial activity was performed against Pseudomonas aeruginosa and Bacillus subtilis. The results showed that the IC50 of all organotin(IV) compounds tested were little bit higher than the chloroquine as the positive control, however one advantage is that the organotin(IV) compounds are not resistent to the Plasmodium, thus making the use of organotin(IV) as anti-malaria is widely opened. The triphenyltin(IV) compound is more potent to be used as anti-malaria and has potential to be developed as anti-malarial drug in the near future. The results of anti-bacterial activity revealed that the triphenyltin(IV) derivative was the most active compound although it is less active compared to the chloramphenicol.

Item Type:	Conference or Workshop Item (Keynote)
Uncontrolled Keywords:	Organotin(IV) carboxylate, antimalarial, antibacterial
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Prof. Sutopo Hadi
Date Deposited:	12 Nov 2020 02:18
Last Modified:	12 Nov 2020 02:18
URI:	http://repository.lppm.unila.ac.id/id/eprint/25017

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