Noviany, Noviany and Osman, Hasnah and Mohamad, Suriyati and Hadi, Sutopo (2020) Antibacterial activity of extracts and compounds from the roots of Sesbania grandiflora (Leguminosae). Research Journal of Chemistry and Environment, 24 (8). pp. 108-113. ISSN 0972-0626

WRA-RJCE-2019-0719 August 2020_108-113.pdf

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Four compounds betulinic acid, 7,4’-dihydroxy-2’- methoxyisoflavan, 3-hydroxy-9-methoxypterocarpan and 7-hydroxy-2’,4’-dimethoxyisoflavan were separated from the roots of Sesbania grandiflora. Structure elucidation of the compounds was determined using UV, IR, MS and NMR spectroscopic techniques. Root extracts and purified compounds were screened for the antibacterial activity by disc-diffusion method against nine bacterial. The activity results of the test components were shown to be dose dependent. The methanol extract displayed the growth inhibition of Streptococcus pyogenes, Bacillus cereus, Staphyloccus aureus and Klebsiella pneumoniae. The acetone extract inhibited the growth of S. pyogenes, B. cereus, S. aureus, Streptococcus pneumoniae, Haemophilus influenzae and K. pneumoniae. The results partially justify the use of S. grandiflora root in traditional medicine to treat diseases caused by bacterial infection.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Dr Noviany
Date Deposited: 11 Nov 2020 08:15
Last Modified: 11 Nov 2020 08:15

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