Anisa, Devi Nur and Afriyani, Hapin (2020) SINTESIS SENYAWA ANALOG KURKUMIN BERBAHAN DASAR VERATRALDEHIDA DENGAN METODE ULTRASOUND. Analit: Analitycal and Environmental Chemistry, 5 (1). pp. 74-81. ISSN 2540-8267

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Abstract

Curcumin is a secondary metabolite compound which is known to have important biological activities, such as antibacterial, anticancer, antioxidant, antidiabetic and anti-inflammatory properties. In this research, synthesis of curcumin analog compound based on veratraldehyde has been performed. The synthesis stage involves the Claisen-Schimdt condensation of veratraldehyde and cyclopentanone using a base catalyst (KOH) in ethanol as a solvent and performed by ultrasound method for 15 minutes, producing a curcumin analogue compound ((2E, 5E) -2,5-bis (3,4-dimethoxibenzylidine) ) cyclopentanon). The results of these compounds were analyzed using DI-MS, and FTIR spectra. The results showed that 15.4 mmol veratraldehyde synthesized with 7 mmol cyclopentanone using a base catalyst (KOH) in ethanol solvent resulted in a yield of 85.71% and a molecular weight of 380 g/mol. The results of the synthesis of curcumin analog compounds from the ultrasound method are yellow solids with a melting point of 194 °C.

Item Type:	Article
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Hapin Afriyani
Date Deposited:	31 May 2020 07:52
Last Modified:	31 May 2020 07:52
URI:	http://repository.lppm.unila.ac.id/id/eprint/21268

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