Suhartati, Tati and Yandri, Yandri and Yuwono, Suripto D. and Qudus, Hardoko Insan and Hadi, Sutopo (2020) In Vivo Antimalarial Test of Artocarpin and in vitro Antimalarial Test of Artonin M Isolated from Artocarpus. Revista de Chimie, 71 (5). pp. 400-408. ISSN 2668-8212

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Abstract

The derivative of flavonoid compounds, artocarpin (1) and artonin M (2), were isolated from the root wood of Artocarpus altilis and from the root bark of A. kemando, respectively. Both plants originated from Lampung, Indonesia. The structure of the two compounds has been carefully determined by physical method and spectroscopy techniques of UV, IR, and NMR. The in vivo antimalarial test of artocarpin showed very good Plasmodium activity in female mice, with ED50 value of 34.88 mg/kg body weight (kgBW), whereas the in vitro antimalarial test of artonin M showed very strong activity with IC50 of 0.3 μg/mL (5.967 x 10-7 M).

Item Type: Article
Uncontrolled Keywords: antimalarial, artocarpin, artonin M, A. altilis, A. kemando
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Prof. Sutopo Hadi
Date Deposited: 30 May 2020 03:06
Last Modified: 30 May 2020 03:06
URI: http://repository.lppm.unila.ac.id/id/eprint/21136

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