Evi, Kurniawaty and Sumaryati, Syukur and Yan, Wirasti and Eti, Yerizel (2019) CORRELATION BETWEEN OBESITY AND TYPE 2 DIABETES MELLITUS USING PPARγ2 GENE VARIAN. Biochemical and Cellular Archives, 19 (2). pp. 4807-4809. ISSN 4807-4809

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Abstract

ABSTRACT : Obesity is caused by dietary, environmental and genetic factors, with various complications capable of causing inflammation, insulin resistance, hypertension and type 2 diabetes mellitus (type 2 DM). However, peroxisome proliferator activator receptor γ (PPARγ) are genetic variations that influence type 2 DM. Therefore, this study aimed at determining the genetic variation of PPARγ2 gene in DM and non-DM obsessed patients using the analytic observation and cross sectional approaches. A total of 88 patients consisting of 44 type-2DM patients and non-DM patients were used to conduct this research. Microtoise and weight scales were the instruments used to measure the body mass index, while PPARγ2 gene examination used DNA isolation method with PCR. Furthermore, the electrophoresis and results of all samples in sequencing were used to determine the effect of PPARγ2 genes and statistical tests using Chi-Square analysis. The results of statistical tests on the PPARγ2 polymorphism genotype in the DM group were found to be 100% Pro12pro, while the ala12ala and pro12ala contained no genotype. The control group found 84.1% pro12pro wild type genotype, 13.6% pro12ala and 2.3% ala12ala. BMI statistical test results obtained p = 0,000, α = 5%, therefore, there is a significant relationship between BMI in type 2 DM patients with the control group. Based on the results of the study it is concluded that the variation of PPARγ2 Pro12pro gene and body mass index obesity have a significant relationship with people living with type 2 diabetes. Key words : Body mass index, diabetes mellitus type-2, insulin resistance.

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Depositing User:	EVI KURNIA
Date Deposited:	04 Jun 2020 05:04
Last Modified:	04 Jun 2020 05:04
URI:	http://repository.lppm.unila.ac.id/id/eprint/19336

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