Evi, Kurniawaty and Hamim, Sadewa and Sumaryati, Syukur and Yan, Wirasti and Eti, Yerizel (2018) POLYMORPHISM AT THE ANGIOTENSINOGEN GENE (AGT) AS A RISK FACTOR FOR DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE II DIABETES MELLITUS. International Journal of Pharma Bio Sciences. pp. 23-27. ISSN 0975-6299

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Abstract

There are many works reported that angiotensin II type 1 receptor (AGT) gene polymorphisms associated with diabetic nephropathy and has variable expression in different ethnic groups. However, the distribution data of AGT gene polymorphism in patients with diabetic nephropathy in Indonesia is still lacking. This study aimed to determine the polymorphism of AGT gene M235T in patients with Type 2 diabetes mellitus in Yogyakarta, Indonesia. The subjects of the research were 60 patients with Type 2 diabetes, 30 diabetic nephropathy and 30 without nephropathy respectively. Gene polymorphisms were determined by PCR-RFLP method and the PCR products were digested with PsyI restriction enzyme. The results showed the frequency distribution of genotypes of AGT gene in patients with diabetic nephropathy were 23.3% for MM, 26.7% for MT, and 50% for TT respectively and the frequency distribution of genotypes of AGT gene in patients with non diabetic nephropathy were 10% for MM, 53.3% for MT, and 36.7% for TT respectively Genotype TT is more prevalent in the DN group while in the non DN group genotype MT is more prevalent. KEYWORDS: AGTgene, M235T, Diabetes mellitus, Type 2 diabetes, Diabetic nephropathy

Item Type:	Article
Subjects:	R Medicine > R Medicine (General)
Depositing User:	EVI KURNIA
Date Deposited:	04 Jun 2020 05:04
Last Modified:	04 Jun 2020 05:04
URI:	http://repository.lppm.unila.ac.id/id/eprint/19330

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