Hadi, Sutopo and Noviany, Noviany and Suhartati, Tati (2020) Antimalarial Activity of Some Organotin(IV) Chlorobenzoate Compounds against Plasmodium falciparum. Mediterranean Journal of Chemistry, 10 (3). pp. 213-219. ISSN 2028-3997

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Abstract

This paper reported the comparative study on antimalarial activity of some organotin(IV) derivatives with some chlorobenzoic acid derivatives used as the ligands. The compounds were synthesized by reacting the intermediate products of dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, with chlorobenzoic acid. The antimalarial activity was performed against Plasmodium falciparum. The results showed that the IC50 of the compounds tested were about the same with the chloroquine (2 x 10-3 μg/mL) used as the positive control, but unlike chloroquine which has been known to have resistance as antimalarial, these organotin(IV) compounds prepared are not resistant to the Plasmodium. The result also showed that the derivative of triphenyltin(IV) has higher IC50 respective to others.

Item Type: Article
Uncontrolled Keywords: antimalarial activity; comparative study; IC50 ; organotin(IV) chlorobenzoate; P. Falciparum
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Magister Ilmu Kimia
Depositing User: Prof. Sutopo Hadi
Date Deposited: 13 Mar 2020 01:20
Last Modified: 13 Mar 2020 01:20
URI: http://repository.lppm.unila.ac.id/id/eprint/18657

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