Sukohar, Asep and Nurdin, Samsu Udayana (2017) α-Glucosidase Inhibitor and Antioxidant Activity Asssay of Guava Leaf, Cashew Leaf and The Combinations As Antidiabetic Agent. International Journal of Research in Ayurveda and Pharmacy, 8 (Supp 1). ISSN DOI: 10.7897/2277-4343.08145
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Abstract
The leaves of guava and cashew have widely used as antidiabetic. Mechanism of antidiabetic effect on guava and cashew leaf caused by inhibition of α-glucosidase. More over antioxidant activity of guava and cashew leaf are expected decreased risk of DM complications by stop oxidative stress process. This study aimed to analyze the activity of α-glucosidase inhibitor and antioxidant of guava and cashew leaves This study use in vitro model with spectrophotometric method to analyze sample with λ= 517 nm for antioxidant analyze and λ= 405 nm for activity of α-glucosidase inhibitor. The data were analyzed by Analysis of Variance (ANOVA) and Least Significant Difference (LSD) on the real level of 1% and 5% The result showed that guava leaf extract has the highest α-glucosidase inhibitor activity by 97,006 % inhibition with IC50 = 2,16 mg/ml and antioxidant activity by 97,992 % on scavenging DPPH. The combination of guava leaf extract and cashew leaf extract did not give some effect on antioxidant activity or α-glucosidase inhibitor activity. The extract of guava and cashew leaves have α-glucosidase inhibitor activity and antioxidant activity. Combination of the extracts did not give some effect on antioxidant activity or α-glucosidase inhibitor activity. Keywords: Antidiabetic, antioxidant, cashew leaf, guava leaf, α-glucosidase inhibitor
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter |
| Depositing User: | Dr. ASEP SUKOHAR |
| Date Deposited: | 29 May 2017 05:32 |
| Last Modified: | 29 May 2017 05:32 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/1752 |
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