Kanedi, Mohammad (2016) HEALING EFFECT OF LEAF EXTRACT OF CANDLEBUSH (CASSIA ALATA L.) ON CUTANEOUS WOUND INFECTED WITHTRICHOPHYTON RUBRUM. World Journal of Pharmaceutical and Life Sciences, 2 (5). pp. 42-50. ISSN 2454-2229

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Research on antimicrobial activity and healing effect of candlebush (Cassia alataL.) extract on wound has been widely done, but its effect on cutaneous wound that were intentionally inoculated with a specific fungus is not known. This study was set to investigate the healing effects of leaf extract of candlebush on rabbit cutaneous wound that intentionally inoculated with T. rubrum. Eighteen male rabbits were divided into six groups: P0,P1, P2, P3and P4,each consisting of three rabbits. P0is rabbits that treated with distilled water as the control; P1, P2, P3and P4 respectively are the rabbits that received candlebush extract of 15%, 25%, 35%, and 45%; P5is rabbits that weregiven 2% ketoconazole ointment as the positive control. To inflict wound, the withers area on the animal's back were shaved and the shaved skin was then cut of about 2 cm in lenght using surgical blade. The inflicted wound was inoculated with T. rubrum and bandaged with sterile gauze for five days and after which the bandage is opened the treatment is done topically. Five levels of wound score were used as healing parameters namely: 4 (acute stage), 3, 2, 1, and 0 (recover stage). Leaf extracts of candlebush at the concentration of 45% totally heal the wound on day 21 while the positive control, ketoconazole 2%, gave total healing on the day 18. Thus, candlebush extract is potent to heal cutaneous wound infected by Trichophyton rubrum.

Item Type: Article
Subjects: Q Science > QL Zoology
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Depositing User: Drs.M.Si. Mohammad Kanedi
Date Deposited: 31 May 2017 01:20
Last Modified: 31 May 2017 01:20
URI: http://repository.lppm.unila.ac.id/id/eprint/1665

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