Sutopo, Hadi and Noviany, Noviany and Mita, Rilyanti (2018) IN VITRO ANTIMALARIAL ACTIVITY OF SOME ORGANOTIN(IV)2-NITROBENZOATE COMPOUNDS AGAINST PLASMODIUM FALCIPARUM. Macedonian Journal of Chemistry and Chemical Engineering, 37 (2). xx-xx. ISSN 1857-5552

Suopo Hadi_In_vitro_antimalarial_activity_of_some_organotinIV.pdf

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Antimalarial activity study of organotin(IV) derivatives with nitrobenzoic acid derivatives used as ligands has been performed. The targeted compounds were prepared from their organotin(IV) chlorides via dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide, and triphenyltin(IV) hydroxide intermediate prod-ucts, followed by reacting the intermediate products with 2-nitrobenzoic acid. The antimalarial activity was performed against P. falciparum. The results showed that the IC50 values of dibutyiltin(IV) di-2-nitrobenzoate, diphenyltin(IV) di-2-nitrobenzoate, and triphenyltin(IV) 2-nitrobenzoate were in 8.4 × 10-3, 5.3 × 10–2, and 9.1 × 10–3 μg/ml, respectively. The IC50 values were slightly higher than the value for chloroquine (2 × 10–3 μg/ml) used as the positive control; however, one advantage is that all prepared organotin(IV) compounds were not resistant to Plasmodium, making the use of organotin(IV) as an anti-malarial is possible. The results indicated that the derivative of triphenyltin(IV) was more potent when used as an antimalarial, as expected, and has potential to be developed as an antimalarial drug in the fu-ture.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Dr Noviany
Date Deposited: 14 Nov 2019 07:40
Last Modified: 14 Nov 2019 07:40

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