Sutopo, Hadi and Noviany, Noviany and Hardoko, Insan Qudus and Pakorn, Wattana-Amorn (2019) The Potency Study of Organotin(IV) 3-Nitrobenzoate Compounds as Antimalarial Agents. Journal of Physics: Conf. Series, 1338 (012012). pp. 1-7. ISSN 1742-6588 Online ISSN: 1742-6596

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Abstract

This paper reports the potency study of organotin(IV) 3-nitrobenzoate as antimalarial agent. The organotin(IV) 3-nitrobenzoate compounds were synthesized by reacting the intermediate products dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, with 3-nitrobenzoic acid. The antimalarial activity study was performed against Plasmodium falcifarum and the result of IC50 of the three compounds tested, i.e. dibutyltin(IV) di-3- nitrobenzoate, diphenyltinIV) di-3-nitrobenzoate and triphenyltin(IV) 3-nitrobenzoate were 8.1 x 10-3, 5.2 x 10-2 and 7.2 x 10-3 µg/mL, respectively, while the the chloroquine gave IC50 2 x 10-3 µg/mL). The IC50 of the compounds tested were little bit higher than the positive control, however these organotin(IV) compounds synthesized are not resistent to Plasmodium, thus the possible development as antimalarial agent is widely opened.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Dr Noviany
Date Deposited: 14 Nov 2019 07:40
Last Modified: 14 Nov 2019 07:40
URI: http://repository.lppm.unila.ac.id/id/eprint/16005

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