Noviany, Noviany and Dicky, Sialdian and Andi, Setiawan and Sutopo, Hadi and Bambang, Irawan and Mohamad, Nurul Azmi (2019) Isolation and Separation Bioactive Secondary Metabolites from Jengkol Plant (Archidendron jiringa (Jack) I. C. Nielsen) Through Bioassay Guided Fractination Approach. In: The 14th Joint Conference On Chemistry, 10-11 September 2019, Solo Paragon Hotel, Surakarta, Indonesia. (Unpublished)

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Abstract

Infectious diseases caused by bacteria has become the global health issues especially antibacterial drug resistance. The most serious concern with antibacterial resistance is that some bacteria have become resistant to almost all antibacterial drugs and making them less effective. Plants are the one of the most important natural resources because they are relatively less side effects and cheap. One of the potential plants that has antibacterial properties is the jengkol plant (Archidendron jiringa (Jack) I. C. Nielsen). Jengkol plant is the one of Lampung's natural resources that has not been optimally used, particularly in the field of technology development and drug health. In current research, isolation and separation secondary metabolites of the roots bark of A. jiringa have been conducted through Bioassay Guided Fractination Approach. Bioactive secondary metabolites from jengkol plant roots has been carried out using general isolation procedures including extraction with maceration method, fractionation and purification by various chromatographic techniques such as vacuum chromatography (VLC), column chromatography (CC) and medium performance liquid chromatography (MPLC). The preliminary identification of bioactive metabolites were recognized by TLC monitoring and 1H-NMR spectroscopy analysis, and its displayed a good antibacterial activity against resistant bacteria, S. aureus and E. coli with the same MIC value of 25 g / mL Based on the 1H-NMR spectroscopy analysis, the major compound identified on the bioactive metabolites was predicted as a phenolic compound. However, the purification of these bioactive metabolites is still in progress and will be reported in the future. Keywords: Archidendron jiringa; jengkol plant; bioassay guided fractionation; antibacterial activity; Staphylococcus aureus; Escherichia coli;

Item Type: Conference or Workshop Item (Speech)
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Dr Noviany
Date Deposited: 14 Nov 2019 07:41
Last Modified: 14 Nov 2019 07:41
URI: http://repository.lppm.unila.ac.id/id/eprint/15986

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