Noviany, Noviany and Osman, Hasnah and Mohamad, Suriyati and Keng Chong, Wong and Awang, Khalijah and Safirah Mohd Zahariluddin, Anis (2012) The Chemical Components of Sesbania grandiflora Root and Their Antituberculosis Activity. Pharmaceuticals, 5. p. 882. ISSN 1424-8247

This is the latest version of this item.

[img] Text

Download (178kB)
Official URL:


Three isoflavanoids, isovestitol (1), medicarpin (2), and sativan (3), along with another known compound, betulinic acid (4), were isolated from the root of Sesbania grandiflora. The structures of the isolated compounds were characterised by means of spectroscopic techniques (UV, IR, MS, 1H- and 13C-NMR, DEPT, COSY, HMQC, HMBC, and MS analysis). All the tested compounds 1–4 exhibited antituberculosis activity against Mycobacterium tuberculosis H37Rv, with MIC values of 50 μg/mL for compounds 1–3, and 100 μg/mL for compound 4, whereas, the methanol extract exhibited antituberculosis activity of 625 μg/mL. This is the first report on the occurrence of isoflavonoids in this plant and their antituberculosis activity.

Item Type: Article
Subjects: Q Science > QD Chemistry
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User: Dr Noviany
Date Deposited: 21 Nov 2016 07:23
Last Modified: 21 Nov 2016 07:23

Available Versions of this Item

Actions (login required)

View Item View Item