Kanedi, Mohammad (2018) Expression of HIF-1, VEGF-β and Caspase-3 in Myocardium of Rats Subjected to Hypoxic-Hyperglycemic Condition. International Journal of Biomedical Research, 09 (12). pp. 403-408. ISSN 0976-9633

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Abstract

Introduction: Studies of the protective effects of insulin on endothelial impairments are still very limited. Aim: This study is intended to find out the effect of insulin injection on expression of HIF-1, VEGF-β, and caspase-3 in myocardial tissues of rats subjected to hypoxic-hyperglycemic condition. Materials and methods: Wistar rats (n=30) were subjected to hyperglycemic by alloxan injection and be hypoxic by exposuring the animal to a normal and low oxygen tension alternatingly. The test animals then grouped into two. The first group was treated with insulin NPH, the second one was not. Results: Results showed that expression of HIF-1 and caspase-3 did not significantly affected by insulin treatments. However, expression of VEGF-β was significantly increased by insulin injection. Conclusion: In conclusion, insulin has potential to be used as a protective agent against endothelial impairments in rats experienced hypoxia and hyperglycemia.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Depositing User: Drs.M.Si. Mohammad Kanedi
Date Deposited: 08 May 2019 07:11
Last Modified: 08 May 2019 07:11
URI: http://repository.lppm.unila.ac.id/id/eprint/11640

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