Dewi Puspita Sari, Ratna and Ristyaning Ayu, Putu and Utami, Nurul and Graharti, Risti (2018) Indeks Trombosit Pada Penderita Preeklampsia di RSUD DR. H. Abdul Moeloek Provinsi Lampung. JURNAL KEDOKTERAN UNIVERSITAS LAMPUNG, 2 (2). ISSN ISSN 2527-3612
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Abstract
Preeclampsia in pregnancy is a widespread abnormality of endothelial or vascular endothelial malfunction resulting in vasospasm after 20 weeks' gestation. Preeclampsia leads to decreased organ perfusion and endothelial activation leading to hypertension, edema, and proteinuria> 300 mg per 24 hours or 30 mg / dl (+1 on dipstick) with very fluctuating values at the time of urine removal.1 Platelet size, when measured as the mean platelet volume (MPV), is an indicator of platelet activity. Larger platelets have greater protrombotic potential, enzymatic and metabolic activity.1 Placental Ischemia will produce free radicals that cause the formation of fatty peroxides that will form toxic radicals and damage endothelial cells. Placental ischemia is also followed by the release of a number of vasoactive factors (TNF-α and IL) that interfere with endothelial function, platelet function and alter the balance between vasoconstriction and vasodilation.2 The occurrence of vasospasm also induces platelet aggregation and endothelial damage that adds to the contribution in maintaining platelet dysfunction and triggers platelet wear. The occurrence of thrombocytopenia is the most important sign of the severity of preeclampsia. In 50% of cases preeclampsia is associated with thrombocytopenia
| Item Type: | Article |
|---|---|
| Subjects: | R Medicine > RG Gynecology and obstetrics |
| Divisions: | Fakultas Kedokteran (FK) > Prodi Pendidikan Dokter |
| Depositing User: | dr, Sp.OG RATNA DEWI PUSPITA SARI |
| Date Deposited: | 02 Jan 2019 07:57 |
| Last Modified: | 02 Jan 2019 07:57 |
| URI: | http://repository.lppm.unila.ac.id/id/eprint/10418 |
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