Hadi, Sutopo and Noviany, Noviany (2018) The in vitro Antimalaria Activity of Some Organotin(IV) benzoate compounds against Plasmodium falcifarum. In: SEMIRATA-International Conference on Science and Technology (ICST) 2018, 4-6 May 2018, Medan, Sumatera Utara.

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Abstract

The organotin(IV) carboxylate and its derivatives are widely known since the derivative of these compounds are very active and strong even at very low concentration. This condition makes these compounds continue to attract more attention to be used in many biological activity testing. We have previously succeeded in the syntheses and performed many activity studies of some organotin(IV) benzoates, in this work, we reported the initial study of antimalaria activity study of some organotin(IV) derivatives with nitrobenzoic acid used as the ligand. The targeted compounds were prepared from their organotin(IV) chlorides via the intermediate products of dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide, respectively and followed by reacting the intermediate products with benzoic acid. The antimalaria activity was performed against Plasmodium falcifarum. The results showed that the IC50 of all organotin(IV) compounds tested were little bit higher than the chloroquine as the positive control, however one advantage is that the organotin(IV) compounds are not resistent to the Plasmodium making the used of organotin(IV) as antimalaria is widely opened. The triphenyltin(IV) compound is more potent to be used as antimalaria and has potential to be developed as antimalarial drug in the near future.

Item Type:	Conference or Workshop Item (Speech)
Subjects:	Q Science > QD Chemistry
Divisions:	Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Kimia
Depositing User:	Prof. Sutopo Hadi
Date Deposited:	16 Nov 2018 17:34
Last Modified:	16 Nov 2018 17:34
URI:	http://repository.lppm.unila.ac.id/id/eprint/10175

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