Nurcahyani, Endang (2019) ANTIHYPERURICEMIA ACTIVITYOF VANILLA (Vanilla planifolia Andrews) FRUITS ETHANOL EXTRACT TO MICE (Mus musculus L.) MALE. In: ICBS 2019 The 6th International Conference on Biological Sciences, 10-11 Oktober 2019, UGM Yogyakarta. (Submitted)


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Abstract: Antihyperuricemia activity test from vanilla (Vanillaplanifolia Andrews) fruit extract on male mice. Hyperuricemia is a disease caused by an increase in uric acid levels in the blood over the normal level. Increased uric acid levels happen because the levels of purines in the body are quite high, so that the breakdown of purines into uric acid increases. This study used dried vanilla fruit extracted using a 60% ethanol solvent. The test animals used were 24 mice which were divided into 6 groups namely group Kn (standard feed), group K- (induced with suspension of chicken liver), group K + (induced by suspension of chicken liver and given allopurinol 10 mg / kgBB), group treatments P1, P2, and P3 were induced by suspension of chicken liver and were given vanilla fruit extract with doses of 50 mg / kgBB, 100 mg / kgBB, and 200 mg / kgBB respectively. Statistical data analysis using ANOVA (Analysis of Variance) through the SPSS 15.0 program with a level of α = 5% and continued with Duncan test at the level of α = 5%. The results of this study showed that vanilla fruit extract treatment P1, P2, and P3 had the potential to be antihyperuricemia, because it can reduce blood uric acid levels in mice induced by the chicken liver. The antihyperuricemia activity of vanilla fruit extract is comparable to the standard allopurinol chemical drug in reducing blood uric acid levels in mice statistically. Key Words: Allopurinol, Antihyperuricemia, Uric Acid, Vanilla planifolia Andrews and Xanthine oxidase

Item Type: Conference or Workshop Item (Speech)
Subjects: Q Science > Q Science (General)
Divisions: Fakultas Matematika dan Ilmu Pengetahuan Alam (FMIPA) > Prodi Biologi
Date Deposited: 14 Nov 2019 10:52
Last Modified: 14 Nov 2019 10:52

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